GlobWat uses spatially distributed input layers consisting of monthly precipitation, number of wet days per month, coefficient of variation of precipitation, monthly reference evapotranspiration, maximum soil moisture storage capacity, maximum percolation flux, irrigated areas, land use, and areas of open water and wetlands. All these input layers are based on freely available spatial dataset with a resolution of 10 arc minutes for the climate dataset and 5 arc minutes for all the terrain and land dataset (data sources are provided in the downloadable files).

The water balance is calculated in two steps. First a vertical water balance is calculated that includes rainfall dependent evapotranspiration and evapotranspiration from crops under irrigated circumstances (for which it is assumed that it can be provided by surface water or groundwater). In a second stage, a horizontal water balance is calculated to correct for incremental evapotranspiration from open water and wetlands and to calculate discharges from river (sub-) basins taking into consideration the water needed for irrigation.